These drugs could cause side effects, including vulnerability to illness and risk of reduced fertility. This fresh check can accurately measure response to treatment, allowing clinicians to tailor treatments to individual individuals. The test works by identifying the quantity of a cytokine molecule known as monocyte chemoattractant proteins-1 present in the urine. MCP-1 is usually produced by the physical body as a response to inflammation, and attracts white blood cells to the region to combat pathogens. However, overreaction of the white blood cells may cause vasculitis and organ damage also..Thus, all scholarly study participants discontinued their RLS medications at least 14 days before starting the analysis medications. Medication was administered orally, 1 to 3 hours before bedtime. The use of concomitant RLS medicines was not allowed. Visits were scheduled at the start of treatment and at 2, 6, 10, 12, and 14 weeks following the begin of treatment; , visits were monthly. Sufferers also completed daily logs of symptoms during the full week preceding each check out. At each check out, the patient, with an investigator, completed the IRLS severity level,25 the Augmentation Severity Rating Level ,28 and the Organized Interview for the Medical diagnosis of Augmentation during RLS treatment,29 a number of nested questions based on the NIH criteria for RLS augmentation22 .30,31 Identification of cases of possible augmentation was predicated on clinical judgment, a total ASRS score of 5 or more, or a positive SIDA score.