Remember, the adrenals create stress hormones and without them – your capability to handle tough circumstances is diminished. According to Dr. Lucille, ‘during stress, the adrenal glands stockpile this antioxidant to safeguard against free-radical damage. However, ongoing stress depletes this essential nutrient from the adrenal glands.’ By the way, Dr. Lucille recommends at least 250 to 500 milligrams each day of supplement C for anyone concerned about the negative effects of stress and maintaining a crystal clear mind.However, people with only one copy of the inactive variant may become tolerant to the unpleasant effects of acetaldehyde, which places them at risk for alcohol-related esophageal cancer. A series of epidemiologic studies by Akira Yokoyama and his colleagues in Japan have shown that folks with one duplicate of the inactive variant are about 6-10 times more likely to develop esophageal cancer than are individuals with the fully active ALDH2 enzyme who beverage comparable amounts of alcohol. Notably, these studies showed that individuals with the inactive variant who drink the same as 33 or more U.S. Regular drinks per week possess a 89-fold improved risk of esophageal cancer compared to nondrinkers.