Our research allowed for the addition of a low-dosage glucocorticoid at the proper period of biologic progression, which appeared to offer disease control in some sufferers. One limitation of the analysis was that patients received treatment off-protocol at the time of disease progression to symptomatic myeloma. It could have been useful to examine early treatment with lenalidomide and dexamethasone versus treatment with lenalidomide and dexamethasone that was deferred until the time of progression.Studies have shown that in Alzheimer's disease and related disorders there can be an abnormal accumulation of amyloid in the mind that is believed by researchers to donate to the dysfunction and eventual loss of life of neuronal cells. When amyloid accumulates and aggregates in the Alzheimer's disease procedure, amyloid deposits seeing that either structures known as amyloid plaques around neuronal cells or deposits of amyloid in the blood vessels of the brain. The group assessed cognitive skills at intervals and found that at three months, the model with human brain blood vessel amyloid had been cognitively impaired but the model with amyloid plaques were not cognitively impaired. Our email address details are intriguing because it shows up cerebrovascular amyloid instead of amyloid plaques around neuronal cells can be an early impact on cognitive decline, said Dr.