Lars Wallentin, M.D more ., Ph.D., Richard C. Becker, M.D., Andrzej Budaj, M.D., Ph.D., Christopher P. Cannon, M.D.D., Ph.D., Claes Held, M.D., Ph.D., Jay Horrow, M.D., Steen Husted, M.D., D.Sc., Stefan James, M.D., Ph.D., Hugo Katus, M.D., Kenneth W. Mahaffey, M.D., Benjamin M. Scirica, M.D., M.P.H., Allan Skene, Ph.D., Philippe Gabriel Steg, M.D., Robert F. Storey, M.D., D.M., and Robert A. Harrington, M.D. For
They regulate the innate and adaptive immune responses by modulating tolerance or triggering immunity through the release and regulation of varied cytokines.18 Immunologic memory is a fundamental feature of the adaptive immune system, and DENND1B is significantly up-regulated in effector memory T cells as compared with naive T cells,19 suggesting a role of DENND1B in the immune response to previously encountered pathogens.20 T cells are activated through exposure to antigens on the surface of dendritic cells. In conclusion, we’ve replicated the association between asthma and the 17q21 locus and have recognized a locus on chromosome 1q31 that’s significantly associated with moderate-to-serious, persistent asthma. We observed a replication of the association in an independent cohort of people of North European ancestry who acquired asthma and in a cohort of American persons of African ancestry who acquired asthma.