Another is definitely low-grade inflammation throughout the body – – circumstances that is observed in diabetes and additional chronic health conditions. Obesity could be part of the puzzle, too, Srikanth said. There is ‘an interesting body of proof’ tying obesity to tau, he described. Just this week, a U.S. Research in Molecular Psychiatry reported a connection between middle-age obesity and previous Alzheimer’s onset. Human brain autopsies also uncovered that Alzheimer’s individuals who’d been large at age group 50 had more mind tangles than those who’d been at regular weight.Sulkowski, M.D., Gregory T. Everson, M.D., Michael W. Fried, M.D., Michael Adler, M.D., Ph.D., Hendrik W. Reesink, M.D., Ph.D., Marie Martin, Ph.D., Abdul J. Sankoh, Ph.D., Nathalie Adda, M.D., Robert S. Kauffman, M.D., Ph.D., Shelley George, M.D., Christopher I. Wright, M.D., Ph.D., and Fred Poordad, M.D. For the ILLUMINATE Research Team: Response-Guided Telaprevir Mixture Treatment for Hepatitis C Virus Infection Chronic infection with hepatitis C virus represents a significant health issue for nearly 200 million contaminated persons worldwide.1 Achievement of a sustained virologic response might be associated with improved long-term scientific outcomes, including increased survival.2,3 In patients contaminated with HCV genotype 1, 48 several weeks of treatment with peginterferon alfa and ribavirin results in a rate of sustained virologic response of 40 to 50 percent.4,5 Telaprevir administered in conjunction with peginterferon and ribavirin has resulted in high rates of sustained virologic response in phase 2 and phase 3 trials involving patients with HCV genotype 1 infection, who have not received treatment previously, in the United European countries and States.6-8 Telaprevir is an orally bioavailable inhibitor of the non-structural 3/4A HCV protease.